Xerostomia Research Today is a free monthly online journal that collates and summarizes the latest research about Xerostomia, including details on dry mouth, treatment, causes, lack of saliva.

The sparkle of the eye: the impact of ocular surface wetness on corneal light reflection.

Goto E, Dogru M, Sato EA, Matsumoto Y, Takano Y, Tsubota K

Department of Ophthalmology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Yokohama City, Kanagawa, Japan 230-8501. goto-e@tsurumi-u.ac.jp

Published 22 March 2011 in Am J Ophthalmol, 151(4): 691-696.e1.
Full-text of this article is available online (may require subscription).

Articles on Xerostomia published 28 February 2011:

Potential benefits of scanned intensity-modulated proton therapy versus advanced photon therapy with regard to sparing of the salivary glands in oropharyngeal cancer.   Int J Radiat Oncol Biol Phys, 79(4): 1216-24.

[Abstract] [Full-text]

Articles on Xerostomia published 7 February 2011:

Cell therapy for salivary gland regeneration.   J Dent Res, 90(3): 341-6.

There are still no effective therapies for hyposalivation caused by irradiation. In our previous study, bone marrow stem cells can be transdifferentiated into acinar-like cells in vitro. Therefore, we hypothesized that transplantation with bone marrow stem cells or acinar-like cells may help functional regeneration of salivary glands. Bone marrow stem cells were labeled with nanoparticles and directly co-cultured with acinar cells to obtain labeled acinar-like cells. In total, 140 severely ... [Abstract] [Full-text]

Articles on Xerostomia published 25 January 2011:

Modeling Sjögren's syndrome with Id3 conditional knockout mice.   Immunol Lett, 135(1): 34-42.

The Id3 gene has been shown to play important roles in the development and function of broad tissue types including B and T cells. Id3 deficient mice develop autoimmune disease similar to human Sjögren's syndrome. Both B and T lymphocytes have been implicated to contribute to the disease phenotype in this disease model. In order to gain a better understanding of individual cell types in this disease model, we generated an Id3 conditional allele. An LckCre transgene was used to induce Id3 ... [Abstract] [Full-text]

Articles on Xerostomia published 24 January 2011:

Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients.   Invest Ophthalmol Vis Sci, 52(1): 456-61.

[Abstract] [Full-text]

Articles on Xerostomia published 17 January 2011:

Endoscopic treatment of salivary glands affected by autoimmune diseases.   J Oral Maxillofac Surg, 69(2): 476-81.

[Abstract] [Full-text]

Articles on Xerostomia published 4 January 2011:

Efficacy and safety of an intraoral electrostimulation device for xerostomia relief: a multicenter, randomized trial.   Arthritis Rheum, 63(1): 180-90.

[Abstract] [Full-text]

Articles on Xerostomia published 6 December 2010:

Phenotypic diversity of peripheral blood plasma cells in primary Sjögren's syndrome.   Scand J Immunol, 73(1): 18-28.

Production of autoantibodies is one of the main features of primary Sjögren's syndrome (pSS). Long-lived plasma cells (PC) can produce autoantibodies for prolonged period of times without being affected by immunosuppressive therapies. As of today, little is known about the long-lived PC subset and their contribution to autoimmunity. We have characterized the phenotypic and migratory properties of peripheral blood PC isolated from pSS patients (grouped by focus score, FS) and compared them to ... [Abstract] [Full-text]

Articles on Xerostomia published 5 November 2010:

Preclinical validation of salivary biomarkers for primary Sjögren's syndrome.   Arthritis Care Res (Hoboken), 62(11): 1633-8.

[Abstract] [Full-text]

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